P2X Receptors: Epithelial Ion Channels and Regulators of Salt and Water Transport

Wildman, Scott S.P. and King, Brian F. (2008) P2X Receptors: Epithelial Ion Channels and Regulators of Salt and Water Transport. Nephron Physiology, 108 (3). p60-p67. ISSN 1660-2137

Abstract

When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion channels, P2X receptors, play a specialized role in the regulation of ion and water movement across the renal tubule and are integral to electrolyte and fluid homeostasis. In this short review, we discuss the concept of P2X receptors as regulators of salt and water salvage pathways, as well as acknowledging their accepted role as ATP-gated ion channels.

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Official URL:	https://doi.org/10.1159/000122028
Item Type:	Article
Disciplines:	?? Biology ??
Depositing User:	Saxony Anders
Date Deposited:	20 Jul 2023 13:50
Last Modified:	16 Jan 2024 10:33
URI:	https://nul.repository.guildhe.ac.uk/id/eprint/72

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